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 In this study, Wedekind had a group of female college students smell T-shirts that had been worn by male students for three nights, without deodorant, cologne or scented soaps.
Overwhelmingly, the women preferred the odors of men with the most dissimilar MHCs to their own (see: adjacent video).
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By having singles send in saliva samples, the site facilitates a laboratory analysis of each person's immune system type and, using this data, claims to create optimized “physical chemistry” or "sexual chemistry" between people based on the sweaty T-shirt study, a pattern, discovered in 1995, which finds that people are most attracted to the smell of people who have the most-dissimilar immune system.
 The site was conceived by Holzle, a long-time internet site dater, after watching a TV discussion on the findings of the sweaty T-shirt study.
The theory of desired dissimilar immune system matching can be quantified according to markers on a person’s major histocompatibility complex (MHC), a large gene region that controls the immune system response, and postulates that couples attracted to this type of scent owing to the result that a resultant child would create a more robust immune system, more defensive against a greater variety of pathogens.